Plot (Spoiler)

The Griffins decide to take a trip to the Grand Canyon. They inadvertently leave Stewie in the house, not realizing it until they are in New York (where they call Cleveland and Quagmire to check on him). When Stewie realizes he is alone, he decides to enjoy his solitude. Cleveland and Quagmire arrive, and Stewie mistakes them for intruders and sprays them with tear gas. Realizing his mistake, he chains them to the Griffins’ basement wall and leaves the DirecTV instructional channel on to occupy their attention. Lois becomes worried after not hearing from Cleveland or Quagmire, so the Griffins return home. After Stewie finishes all the food in the house he realizes he needs his family, and embraces them when they return.